Previous studies have demonstrated that patients with low grade TIMI flow prior to percutaneous coronary intervention (PCI) have a less favorable outcome. TIMI flow grade 0 represents total occlusion, while TIMI flow grade 3 represents normal epicardial perfusion. Thrombolysis in Myocardial Infarction (TIMI) coronary grade flow is an established, validated score to assess the epicardial perfusion on coronary angiography. Nevertheless, over time, in-hospital complications have decreased among patients with TIMI 0, while 30d MACE and 1-year mortality has remained unchanged. TIMI flow grade 0 is still more common among patients with STEMI and is associated with poorer prognosis. There was no temporal change of these outcomes in either TIMI flow grade group. Compared with TIMI flow 1–3, patients with TIMI flow 0 had worse 30d MACE and 1-year mortality. In-hospital complications of patients with TIMI flow 0 has significantly decreased over time (36.1% vs 26.8%, P < 0.001) but not amongst patients with TIMI flow 1–3. The majority of patients had pre-procedural TIMI flow 0 (58.9% in the early period and 58.7% in the late period, P = 0.97). Results and Conclusions: Included were 2453 patients. Clinical outcomes included in-hospital complications, 30d MACE (death, myocardial infarction, stroke, unstable angina, stent thrombosis, urgent revascularization) and 1-year mortality. Survey years were divided to early (2008–2010) and late period (2013–2018). A time-dependent analysis stratifying patient by TIMI flow grade 0 and TIMI flow grade 1–3 was performed. TIMI 2 flow (partial reperfusion) is delayed or sluggish antegrade flow with complete filling of the distal territory.Data of patients with STEMI from the acute coronary syndrome Israeli Survey (ACSIS) registry.TIMI 1 flow (penetration without perfusion) is faint antegrade coronary flow beyond the occlusion, with incomplete filling of the distal coronary bed.TIMI 0 flow (no perfusion) refers to the absence of any antegrade flow beyond a coronary occlusion.'TIMI Grade Flow' is a scoring system from 0-3 referring to levels of coronary blood flow assessed during percutaneous coronary angioplasty: TIMI risk can be calculated on the TIMI website under "Clinical Calculators." 'TIMI risk' estimates mortality following acute coronary syndromes. % risk at 14 days of: all-cause mortality, new or recurrent MI, or severe recurrent ischemia requiring urgent revascularization. ST changes of at least 0.5mm on admission EKG At least 2 angina episodes within the last 24hrs Or female first-degree relative or mother less than 65). (CAD in male first-degree relative, or father less than 55, Such as: Hypertension -> 140/90 or on antihypertensives, Known Coronary Artery Disease (CAD) (coronary stenosis >= 50%) Aspirin use in the last 7 days (patient experiences chest pain despite ASA use in past 7days) TIMI Score Calculation (1 point for each): It is used to categorize a patient's risk of death and ischemic events and provides a basis for therapeutic decision making. The TIMI Risk Score is used in patients with U nstable Angina / Non-ST Elevation Myocardial Infarction. It has conducted numerous practice-changing clinical trials in patients with cardiovascular disease or risk factors for cardiovascular disease TIMI stands for ' Thrombolysis In Myocardial Infarction' and is the name of an Academic Research Organization (ARO) which was founded by Dr.
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